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Author Topic:   Topical N-acetylcysteine as trialled in Spain and reported in the Lancet
heather
Member

Posts: 9
From:Auckland, New Zealand
Registered: Aug 2001

posted October 21, 2001 10:09 PM     Click Here to See the Profile for heather   Click Here to Email heather     Edit/Delete Message   Reply w/Quote
My dermatologist had made a mixture of 10% N-acetylcysteine (an antioxidant)in a water in silicone emulsion, its like a gel, this is to counter the bad smell and to stop it from breaking down. I had read about this treatment being tried in Spain by Dr. Redondo and had taken the article into the derm. about a year ago, for interest. This year when I went back he had the mixture ready, unbeknown to me he had written to Spain (no reply) and had the pharmacology people working on producing it. It took several attempts to get the smell tolerable he said. The Spanish report only mentions one lamellar lady being treated with it with great success.
Anyway I have tried it, and am currently waiting for a 5% formula instead of the 10%. it certainly worked very well at removing all the layers of scale down to a very smooth finish, reminded me of being on accutane, however it burned in many places, hence trying a weaker mixture.It didn't do anything for my hands/neck which are the worst looking for me in terms of lines, but have no scale to remove. On my back/feet it removed all skin to a very smooth finish overnight. However I have not determined yet how quickly you can then apply it again without burning.But in case anyone had read about it and was interested I thought I'd mention it here, and you can contact me if yo want to know more. The Spring Edition of Ichthyosis Focus mentioned it, but said as only 1 patient was mentioned in the trial, its safety/efficacy had not been established,but that if it worked as stated it would be a welcome addition to our therapeutic options.

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gkasche
New member

Posts: 4
From:Seneca, PA U.S.A.
Registered: Sep 2001

posted October 22, 2001 11:40 PM     Click Here to See the Profile for gkasche   Click Here to Email gkasche     Edit/Delete Message   Reply w/Quote
Dear Heather...do you live in the United States? I am very interested in the ointment you mention in your post. How it is mixed up and where it is available. Thanks....Please e-mail me at gkasche@usachoice.net Thanks Karen

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heather
Member

Posts: 9
From:Auckland, New Zealand
Registered: Aug 2001

posted October 24, 2001 01:44 AM     Click Here to See the Profile for heather   Click Here to Email heather     Edit/Delete Message   Reply w/Quote
No Karen, I live in new Zealand. You can see the article I read at www.thelancet.com/newlancet/sub/issues/vol354no9193/research1880.html. I took the article to my dermatologist who had a pharmaceutical firm mix it, he said it took them several attempts to get the smell tolerable. You would have to probably do the same e.g. ask your derm for a prescription to get it mixed. If it proves to be worthwhile e.g. better than using hydroxy acids, I'll try and get the formula from them, or at least the pharmacy mixing it should be prepared to communicate with one in the US on how to do it. The base has to be a kind of silicone gel to keep the N-Acetylcysteine stable. I'll keep you posted.
quote:
Originally posted by gkasche:
Dear Heather...do you live in the United States? I am very interested in the ointment you mention in your post. How it is mixed up and where it is available. Thanks....Please e-mail me at gkasche@usachoice.net Thanks Karen

[This message has been edited by heather (edited October 24, 2001).]

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